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. 2016 Feb 25;13:33. doi: 10.1186/s12985-016-0488-4

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© Al-Khannaq et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Maximum clade credibility (MCC) tree of HCoV-HKU1 genotypes. Estimation of the time of the most recent common ancestors (tMRCA) with 95 % highest posterior density (95 % HPD) of HCoV-HKU1 genotypes based on the spike gene (S1 domain) (897 bp). Data were analyzed under relaxed molecular clock with GTR + I substitution model and a constant size coalescent model implemented in BEAST. The Malaysian HCoV-HKU1isolates obtained in this study were color-coded and the HCoV-HKU1 genotypes (a) to (c) were indicated. The MCC posterior probability values were indicated on the nodes of each genotype