Table 4.
Evolutionary characteristics of HCoV-OC43 and HCoV-HKU1 genotypes
| Subtype-gene evolutionary ratea | Genotype | tMRCAb |
|---|---|---|
| OC43-Spike 7.2 (5.2–9.4) | ||
| all genotypes | 1952.2 (1931.0–1965.2) | |
| genotype A | 1961.8 (1955.1–1966.0) | |
| genotype B | 1991.0 (1981.4–1999.0) | |
| genotype C/D | 2001.7 (2000.1–2002.9) | |
| genotype D | 2004.5 (2003.3–2005.8) | |
| genotype E | 2009.3 (2008.3–2010.0) | |
| novel lineage 1 | 2007.5 (2006.6–2008.0) | |
| novel lineage 2 | 2010.5 (2009.5–2011.4) | |
| HKU1-Spike 6.2 (4.5–8.0) | ||
| all genotypes | 1957.2 (1920.3–1987.5) | |
| genotype A | 1999.4 (1994.8–2002.5) | |
| genotype B | 2001.2 (1997.6–2003.6) | |
| genotype C | 2002.3 (1999.8–2003.8) | |
| HKU1-Nucleocapsid 4.3 (2.8–5.8) | ||
| all genotypes | 1962.0 (1915.1–1994.8) | |
| genotype A | 1986.8 (1970.8–1999.0) | |
| genotype B | 2002.2 (1999.4–2002.2) | |
| genotype C | 2002.3 (2000.1–2003.8) |
aEstimated mean rates of evolution expressed as 10−4 nucleotide substitutions/site/year under a relaxed molecular clock with GTR + I substitution model and an Exponential tree model. The 95 % highest posterior density (HPD) confidence intervals are included in parentheses
bMean time of the most common ancestor (tMRCA, in calendar year). The 95 % highest posterior density (HPD) confidence intervals are indicated