Table 2.
Evolution of metabolic parameters during the study
| M2 | ND | HF | HFD | HFHF |
|---|---|---|---|---|
| Weight (g) | 442 ± 610 | 462 ± 8 | 543 ± 14* | 553 ± 14* |
| Fasting Leptin (ng/mL) | 8.19 ± 0.44 | 10.84 ± 0.75** | 20.86 ± 0.79*** | 17.05 ± 1.68*** a |
| Fasting glycaemia (mg/dL) | 89 ± 4 | 102 ± 6 | 128 ± 6*** | 112 ± 6** |
| Peptide-C (pmol/L) Fasting | 1027.8 ± 71.4 | 2340.2 ± 73.7*** | 1404.5 ± 73.7*** | 2282.6 ± 187.9*** |
| Non-fasting | 1974.5 ± 163.8 | 5222.9 ± 374.1*** | 3578.2 ± 256*** | 4531.3 ± 432.8*** |
| Insulin resistance (HOMA2-IR) | 2.20 ± 0.15 | 3.35 ± 0.33 | 6.59 ± 0.67*** | 5.36 ± 0.79* |
| Total cholesterol (mM) | 2.92 ± 0.41 | 4.0 ± 0.80 | 3.44 ± 0.48 | 5.03 ± 0.73* |
Effects of diet on body weight and metabolic parameters during the study, after 2 (M2) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with age-matched ND rats and abetween HFD- and HFHF-rats. *p<0.05, **p<0.01, ***p<0.001