Table 1.
Function-related clusters of differentially expressed genes for 21d BDS mice sacrificed immediately after the last exposure ended vs. air controls (fold change > 2 and FDR p-value < 0.05)
| Gene symbol | Gene descriptor | Raw estimated fold change BDS 21d vs air control |
|---|---|---|
| Inflammation cluster | ||
| Saa3 | serum amyloid A 3 | 7.86 |
| Cxcl1 | chemokine (C-X-C motif) ligand 1 | 5.42 |
| Reg3g | regenerating islet-derived 3 gamma | 4.75 |
| Orm1 | orosomucoid 1 | 4.73 |
| Cxcl5 | chemokine (C-X-C motif) ligand 5 | 4.43 |
| Ccl20 | chemokine (C-C motif) ligand 20 | 3.60 |
| Vnn1 | vanin 1 | 3.30 |
| Adam8 | a disintegrin and metallopeptidase domain 8 | 3.13 |
| Cfb | complement factor B | 2.61 |
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 2.33 |
| Cd14 | CD14 antigen | 2.07 |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 2.06 |
| Ccl28 | chemokine (C-C motif) ligand 28 | 1.96 |
| Biotransformation cluster | ||
| Cyp1b1 | cytochrome P450, family 1, subfamily b, polypeptide 1 | 25.83 |
| Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | 18.32 |
| Aldh3a1 | aldehyde dehydrogenase family 3, subfamily A1 | 7.97 |
| Ahrr | aryl-hydrocarbon receptor repressor | 3.56 |
| Adh7 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 3.35 |
| Scgb3a1 | secretoglobin, family 3A, member 1 | 3.21 |
| Ltf | lactotransferrin | 2.50 |
| Afp | alpha fetoprotein | 2.31 |
| Steap4 | STEAP family member 4 | 2.07 |
| Itih4 | inter alpha-trypsin inhibitor, heavy chain 4 | 2.02 |
| Oxidative stress cluster | ||
| Nqo1 | NAD(P)H dehydrogenase, quinone 1 | 4.16 |
| Ces1 | carboxylesterase 1 | 3.88 |
| Akr1b8 | aldo-keto reductase family 1, member B8 | 2.02 |
| Acox2 | acyl-Coenzyme A oxidase 2, branched chain | 2.01 |
| Gpx2 | Glutathione peroxidase 2 | 1.97 |