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p53 mutants localization and function.
| P53 mutant | Localization | Ability to induce apoptosis | Transcription independent | Reference |
|---|---|---|---|---|
| L-p53 | M | Yes | Yes | (9) |
| R273H | C | No | (10) | |
| R175H | N, C | No | (11) | |
| L194F | N, C | No | (10) | |
| R280K | N, C | No | (10) | |
| G245S | N, C | No | ||
| R248W | N, C | No | (11) | |
| R249S | N, C | No | (11) | |
| R282W | N | No | (11) | |
| L22Q | N | Yes | Yes | (12) |
| W23S | N | Yes | Yes | (12) |
| ΔNLS | C | Yes | Yes | (13) |
| dl214 | N, C | Yes | Yes | (14) |
| N1–102 | C | Yes | Yes | (13) |
| M246I | N | No | (15) |
N, nucleus; M, mitochondria; C, cytosol.
