Skip to main content
. 2016 Feb 25;6:42. doi: 10.3389/fonc.2016.00042

Table 1.

p53 mutants localization and function.

P53 mutant Localization Ability to induce apoptosis Transcription independent Reference
L-p53 M Yes Yes (9)
R273H C No (10)
R175H N, C No (11)
L194F N, C No (10)
R280K N, C No (10)
G245S N, C No
R248W N, C No (11)
R249S N, C No (11)
R282W N No (11)
L22Q N Yes Yes (12)
W23S N Yes Yes (12)
ΔNLS C Yes Yes (13)
dl214 N, C Yes Yes (14)
N1–102 C Yes Yes (13)
M246I N No (15)

N, nucleus; M, mitochondria; C, cytosol.