Effects of the kappa opioid receptor antagonist JDTic (20 mg/kg) on control nesting or nesting depressed by U69,593, i.p. acid, or i.pl. CFA. Treatments are shown on the abscissa, and the ordinate shows nesting expressed as Number of Zones Cleared. Data were analyzed by two-way ANOVA followed by the Tukey post hoc test. Asterisks indicate a significant effect of JDTic dose within a given depression stimulus: ** p<0.01. Number signs indicate a significant effect of the depression stimulus within a given JDTic dose: # p<0.05, ## p<0.01.