Table 1. World Health Organization recommendations for the programmatic use of bedaquiline and delamanid to treat multidrug-resistant tuberculosis.

Recommendation
1. The drug is used under carefully monitored conditions.
2. Patients to receive the drug are carefully selected.
3. The drug is used as part of a World Health Organization–recommended treatment regimen.
4. Patients to receive the drug sign an informed consent; for delamanid, the recommendation is only for “due process” for informed consent.
5. Adverse events, including active pharmacovigilance, are actively managed.