TABLE 2.
Apparent IC50 values of CU-1 and CU-3 against 10 DGK isozymes
DGK isozyme | IC50 of CU-1 (μM) | IC50 of CU-3 (μM) |
α (type I) | 8 | 0.6 |
β (type I) | 43 | 36 |
γ (type I) | 37 | 28 |
δ (type II) | 33 | 36 |
η (type II) | 32 | 7 |
κ (type II) | 46 | 32 |
ε (type III) | 24 | 8 |
ζ (type IV) | 47 | 30 |
ι (type IV) | 27 | 11 |
θ (type V) | 30 | 15 |