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GlcChol in COS-7 cells manipulated in GSL-metabolizing enzymes. A: GlcCer (nanomoles per milligram protein) in COS-7 cells without overexpression of enzymes (control), overexpressed GBA2, and GCS. Cells were incubated for 2 days with the indicated inhibitors of GBA2 (AMP-DNM) and GBA (CBE). B: GlcChol (picomoles per milligram protein) in same cells. Data (n = 4, mean ± SD) were analyzed using an unpaired t-test. ***P < 0.001.
