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. 2016 Mar;57(3):451–463. doi: 10.1194/jlr.M064923

Fig. 5.

Fig. 5.

GlcChol abnormalities in NPC. A: GlcChol (nanomoles per gram wet weight) in liver of BALB/c Npc1+/+, Npc1+/nih and Npc1nih/nih male mice at 80 days of age (n = 3, mean ± SD). B: GlcChol (nanomoles per gram wet weight) in liver of C57BLKS Npc1+/spm and Npc1spm/spm male mice at 80 days of age (n = 3–5, mean ± SD). C: GlcChol (picomoles per milligram protein) in RAW264.7 cells incubated with the indicated concentration of U18666A for 1 day in the absence and presence of CBE-inhibiting GBA (n = 3, mean ± SD). D: GlcChol picomoles per milligram protein) in RAW264.7 cells incubated with 10 μM U18666A for 8 h and in the subsequent absence or presence of 1 mM β-methyl-cyclodextrin (β-mCD) reducing intralysosomal cholesterol for 18 h (n = 3, mean ± SD). Data were analyzed using an unpaired t-test. **P < 0.01, and ***P < 0.001.