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Schematic diagram of enzymes involved in endocannabinoid synthesis and degradation. A: From membrane phospholipids, 2-AG is produced via DAGLα/β, while AEA, PEA, and OEA synthesis is enabled either directly via NAPE-PLD or by ABHD4 and GDE1. B: The 2-AG is degraded via MGL, whereas AEA, PEA, and OEA are hydrolyzed by FAAH.
