Table 2.
Logistic regression analyses of correlations between WWOX rs10220974C>T, rs12918952G>A, rs3764340C>G, rs1074963C>G, rs383362G>T, rs1424110A>G, and rs12828A>G polymorphisms and risk of osteosarcoma
| WWOX genotype | Cases (N=276)
|
Controls (N=286)
|
Crude OR (95% Cl) | P-value | Adjusted OR (95% Cl) | P-value | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| WWOX rs10220974 C>T | ||||||||
| CC | 211 | 76.45 | 228 | 79.72 | 1.00 | 1.00 | ||
| CT | 61 | 22.10 | 53 | 18.53 | 1.24 (0.82–1.88) | 0.301 | 1.24 (0.82–1.88) | 0.308 |
| TT | 4 | 1.45 | 5 | 1.75 | 0.86 (0.23–3.26) | 0.830 | 0.85 (0.23–3.22) | 0.812 |
| CT + TT | 65 | 23.55 | 58 | 20.28 | 1.21 (0.81–1.81) | 0.349 | 1.21 (0.81–1.80) | 0.360 |
| CC + CT | 272 | 98.55 | 281 | 98.25 | 1.00 | 1.00 | ||
| TT | 4 | 1.45 | 5 | 1.75 | 0.83 (0.22–3.11) | 0.78 | 0.81 (0.22–3.07) | 0.76 |
| WWOX rs12918952 G>A | ||||||||
| GG | 251 | 90.94 | 257 | 89.86 | 1.00 | 1.00 | ||
| GA | 23 | 8.33 | 28 | 9.79 | 0.84 (0.47–1.50) | 0.557 | 0.83 (0.46–1.48) | 0.520 |
| AA | 2 | 0.72 | 1 | 0.35 | 2.05 (0.19–22.73) | 0.559 | 2.25 (0.20–25.13) | 0.509 |
| GA + AA | 25 | 9.05 | 29 | 10.14 | 0.88 (0.50–1.55) | 0.664 | 0.87 (0.50–1.54) | 0.638 |
| GG + GA | 274 | 99.28 | 285 | 99.65 | 1.00 | 1.00 | ||
| AA | 2 | 0.72 | 1 | 0.35 | 2.08 (0.19–23.07) | 0.551 | 2.29 (0.21–25.51) | 0.501 |
| WWOX rs3764340C>G | ||||||||
| CC | 194 | 70.29 | 232 | 81.12 | 1.00 | 1.00 | ||
| CG | 71 | 25.72 | 49 | 17.13 | 1.73 (1.15–2.61) | 0.009* | 1.74 (1.15–2.63) | 0.009* |
| GG | 11 | 3.99 | 5 | 1.75 | 2.63 (0.90–7.70) | 0.078 | 2.57 (0.88–7.56) | 0.086 |
| CG + GG | 82 | 29.71 | 54 | 18.88 | 1.82 (1.23–2.69) | 0.003* | 1.82 (1.22–2.70) | 0.003* |
| CC + CG | 265 | 96.01 | 281 | 98.25 | 1.00 | 1.00 | ||
| GG | 11 | 3.99 | 5 | 1.75 | 2.33 (0.80–6.80) | 0.121 | 2.27 (0.78–6.63) | 0.135 |
| WWOX rs1074963C>G | ||||||||
| CC | 4 | 1.45 | 7 | 2.45 | 1.00 | 1.00 | ||
| CG | 72 | 26.09 | 69 | 24.13 | 1.83 (0.51–6.52) | 0.354 | 1.93 (0.54–6.93) | 0.312 |
| GG | 200 | 72.46 | 210 | 73.43 | 1.67 (0.48–5.78) | 0.421 | 1.79 (0.51–6.24) | 0.363 |
| CG + GG | 272 | 98.55 | 279 | 97.55 | 1.71 (0.49–5.89) | 0.398 | 1.83 (0.53–6.34) | 0.344 |
| CC + CG | 76 | 27.54 | 76 | 26.58 | 1.00 | 1.00 | ||
| GG | 200 | 72.46 | 210 | 73.43 | 0.95 (0.66–1.38) | 0.797 | 0.97 (0.67–1.41) | 0.862 |
| WWOX rs383362G>T | ||||||||
| GG | 190 | 68.84 | 223 | 77.97 | 1.00 | 1.00 | ||
| GT | 77 | 27.90 | 57 | 19.93 | 1.59 (1.07–2.35) | 0.022* | 1.56 (1.05–2.32) | 0.027* |
| TT | 9 | 3.26 | 6 | 2.10 | 1.76 (0.62–5.04) | 0.292 | 1.65 (0.57–4.77) | 0.354 |
| GT + TT | 86 | 31.16 | 63 | 22.03 | 1.60 (1.10–2.34) | 0.015* | 1.57 (1.07–2.30) | 0.020* |
| GG + GT | 267 | 96.74 | 280 | 97.90 | 1.00 | 1.00 | ||
| TT | 9 | 3.26 | 6 | 2.10 | 1.57 (0.55–4.48) | 0.396 | 1.46 (0.51–4.21) | 0.480 |
| WWOX rs1424110A>G | ||||||||
| AA | 88 | 31.88 | 108 | 37.76 | 1.00 | 1.00 | ||
| AG | 136 | 49.28 | 127 | 44.41 | 1.31 (0.91–1.91) | 0.149 | 1.31 (0.90–1.90) | 0.154 |
| GG | 52 | 18.84 | 51 | 17.83 | 1.25 (0.78–2.02) | 0.358 | 1.25 (0.78–2.02) | 0.356 |
| AG + GG | 188 | 68.12 | 178 | 62.24 | 1.30 (0.92–1.84) | 0.144 | 1.29 (0.91–1.83) | 0.148 |
| AA + AG | 224 | 81.16 | 235 | 82.17 | 1.00 | 1.00 | ||
| GG | 52 | 18.84 | 51 | 17.83 | 1.07 (0.70–1.64) | 0.757 | 1.07 (0.70–1.65) | 0.747 |
| WWOX rs12828A>G | ||||||||
| AA | 20 | 7.25 | 24 | 8.39 | 1.00 | 1.00 | ||
| AG | 125 | 45.29 | 135 | 47.20 | 1.11 (0.59–2.11) | 0.747 | 1.09 (0.57–2.08) | 0.796 |
| GG | 131 | 47.46 | 127 | 44.41 | 1.24 (0.65–2.35) | 0.515 | 1.21 (0.63–2.30) | 0.570 |
| AG + GG | 256 | 92.75 | 262 | 91.61 | 1.17 (0.63–2.18) | 0.614 | 1.15 (0.62–2.13) | 0.668 |
| AA + AG | 145 | 52.54 | 159 | 55.59 | 1.00 | 1.00 | ||
| GG | 131 | 47.46 | 127 | 44.41 | 1.13 (0.81–1.58) | 0.467 | 1.12 (0.80–1.56) | 0.502 |
Notes: ORs were adjusted for age and sex.
*
Statistically significant (P>0.05).
Abbreviations: OR, odds ratio; CI, confidence interval.