Table 5.

Total procedure cost calculations per patient based on inputs

	UK		Italy
	Rivaroxaban	Warfarin	Rivaroxaban	Warfarin
Drug cost for 63 days	£13210	£7 (it was assumed that warfarin is used at 4.5 mg)11	€13212	€413
INR monitoring (63 days)	N/A	£256a15	N/A	€271
Cost of cardioversion	£83514	£83514	€676	€662
Additional booked cardioversion procedures per patient–when rescheduled on the scheduled day	0.172	0.477	0.172	0.477
Additional booked cardioversion procedures per patient–when rescheduled prior to the scheduled day	0.058	0.161	0.058	0.161
Cost of nurse specialist per rescheduleb	£6	£6	N/A	N/A
Cost of rescheduling on the scheduled day	£145c	£401	€116	€316
Cost of rescheduling prior to the scheduled day	£0.35	£0.97	N/A	N/A
Cost of additional waiting time for patients on warfarin	N/A	£335,11,14	N/A	€35
Total procedure cost per patient	£1118	£1539	€924	€1289

INR, international normalized ratio; N/A, not applicable; NHS, UK National Health Service.

^aThe INR monitoring required with warfarin was calculated based on weighted average costs taken from NHS reference costs¹⁵ for 5.7 visits prior to cardioversion and 4.7 visits post-cardioversion.

^bThe cost for a specialist nurse is based on 7 min per patient to review INR levels and check suitability for cardioversion, which will have to be repeated if the procedure is rescheduled for a different date. This information has been provided by clinical teams that schedule and perform cardioversion procedures to calculate cost based on NHS nurse salaries.¹⁶

^cThe value shown corresponds to the unit cost of cardioversion (£835) plus the cost for nurse rescheduling (£6.07) multiplied by the probability of rescheduling on the scheduled day (0.172).