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. Author manuscript; available in PMC: 2016 Feb 25.
Published in final edited form as: Nat Genet. 2015 May 11;47(6):615–624. doi: 10.1038/ng.3293

Figure 1.

Figure 1

SB mutagenesis can accelerate or induce osteosarcoma development in cells with Sp7-cre expression. (a) Osteosarcoma-free survival curve depicting time to osteosarcoma development and survival endpoints in all cohorts. Control mice contained Sp7-cre with either SB11 or T2/Onc. ***P < 0.0001, log-rank test. (b) Histogram displaying the number of osteosarcomas per mouse. *P = 0.0159, Student's t test. (c) Representative SKY results from analysis of osteosarcoma tumor cells that developed in Trp53-C, Trp53-SBmut and SBmut mice. (d,e) Histograms demonstrating the number of chromosomal aberrations (d) and whole-chromosome gains and/or losses (e) identified by aCGH performed on Trp53-C (n = 4), Trp53-SBmut (n = 5) and SBmut (n = 4) osteosarcoma tumor DNA with matched normal tail DNA. *P < 0.05, **P < 0.001, Student's t test. Error bars, s.d.