Table 3.

Multivariate analysis of factors associated with composite endpoint in the all AF population

	Composite endpoint RR (95% CI)	Death RR (95% CI)	Bleeding RR (95% CI)	Arterial thombosis RR (95% CI)	MI or ACS RR (95% CI)
Gender Male	1.23 (0.98,1.53)	1.59 (1.12, 2.25)	1.04 (0.70, 1.53)	1.56 (0.89, 2.76)	0.64 (0.38,1.08)
Age at index date (in categories)
< 65 years	1	1	1	1	1
[65–74] years	1.05 (0.74, 1.50)	1.10 (0.63,1.92)	1.25 (0.61,2.54)	1.03 (0.45,2.37)	0.85 (0.39,1.88)
[75–84] years	1.14 (0.82,1.58)	0.97 (0.58,1.64)	1.69 (0.89,3.21)	1.09 (0.51,2.35)	1.00 (0.49,2.05)
> 84 years	2.40 (1.68,3.43)	3.17 (1.87,5.38)	3.08 (1.53,6.23)	1.89 (0.78,4.54)	0.90 (0.36,2.28)
Congestive heart failure	1.34 (1.07, 1.69)	1.77 (1.26,2.48)	1.07 (0.70,1.64)	1.51 (0.87,2.65)	1.04 (0.60,1.81)
Hypertension	1.25 (1.00, 1.57)	1.04 (0.74,1.48)	1.52 (1.01,2.28)	1.02 (0.58,1.78)	1.81 (1.02,3.21)
Vascular disease history	1.60 (91.26,2.04)	1.56 (1.07,2.28)	0.90 (0.56,1.46)	2.38 (1.34,4.21)	2.18 (1.28,3.72)
Bleeding history	1.41 (0.72,2.76)	0.72 (0.18,2.93)	3.19 (1.37,7.46)	0.96 (0.13,7.08)	0.87 (0.12,6.41)
Medication use predisposing to bleeding	1.06 (0.85,1.31)	0.58 (0.41,0.82)	1.38 (0.93,2.02)	1.08 (0.63,1.87)	2.85 (1.56,5.19)
Stroke history	1.39 (1.03,1.87)	1.67 (1.08,2.59]	1.42 (0.85,2.38)	1.90 (0.95,3.79)	0.70 (0.28,1.75)
Diabetes mellitus	1.16 (0.92,1.46)	0.98 (0.68,1.41)	0.98 (0.64,1.48)	1.39 (0.80,2.42)	1.66 (1.00,2.78)
Abnormal renal function	1.70 (1.29,2.24)	2.32 (1.56,3.44)	1.31 (0.76,2.24)	1.32 (0.64,2.70)	1.40 (0.72,2.71)
Abnormal liver function	1.08 (0.55,2.12)	1.81 (0.78,4.22)	0.48 (0.07,3.50)	1.40 (0.33,5.96)	0.53 (0.07,3.91)
Cancer in the two previous years	2.10 (1.55,2.85)	2.09 (1.32,3.29)	2.97 (1.80,4.88)	1.15 (0.45,2.92)	1.44 (0.61,3.37)

Reference groups are female gender, or the absence of the relevant condition;

RR (95% CI), relative risk and 95% confidence interval.