Table 4.
Event rates for all AF and non‐AF populations during VKA exposure and after VKA withdrawal per 100 patient‐years
| All AF During exposure | All AF After exposure | RR (95% CI) After exposure/during exposure | No AF During exposure | Non‐AF After exposure | RR (95% CI) After exposure/during exposure | |
|---|---|---|---|---|---|---|
| Patient‐years | 3977 | 1214 | 4233 | 3431 | ||
| Composite outcome (n, %) | 362 (9.1) | 206 (17.0) | 1.86 (1.59,2.18) | 296 (7.0) | 235 (6.9) | 0.98 (0.83, 1.16) |
| Death n (%) | 152 (3.8) | 142 (11.7) | 3.06 (2.46,3.81) | 117 (2.8) | 145 (4.2) | 1.53 (1.21, 1.93) |
| Major bleeding n (%) | 113 (2.8) | 23 (1.9) | 0.67 (0.43, 1.04) | 97 (2.3) | 43 (1.3) | 0.55 (0.38, 0.78) |
| Thrombotic event n (%) | 58 (1.5) | 31 (2.6) | 1.75 (1.14, 2.70) | 58 (1.4) | 46 (1.3) | 0.98 (0.67, 1.43) |
| Acute coronary event n (%) | 64 (1.6) | 23 (1.9) | 1.18 (0.73, 1.89) | 37 (0.9) | 21 (0.6) | 0.70 (0.41, 1.19) |
AF, atrial fibrillation.