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. 2016 Jan 8;81(3):553–561. doi: 10.1111/bcp.12821

Table 2.

Population pharmacokinetic parameter values ± standard deviation estimated in dihydropyrimidine dehydrogenase (DPD)‐deficient subjects (EURDEF model), subjects with normal DPD activity (EURNOR model) and all subjects (EURMIX model)

Km (mg l −1 ) V max (mg h −1 *1.85m −2 ) ka po (h −1 ) V(l)
EURDEF 5.99 ± 4.17 494 ± 133 5.61 ± 7.16 0.57 ± 0.09
EURNOR 7.69 ± 1.38 837 ± 130 4.65 ± 3.33 0.51 ± 0.14
EURMIX 7.10 ± 3.33 641 ± 178 5.13 ± 4.87 0.55 ± 0.12

Ka, absorption constant; Km, Michaelis–Menten constant; po, per oral; V, apparent volume of drug distribution; Vmax, maximum enzymatic conversion capacity.