Table 2.
Events | All-Cause Mortality |
Unadjusted |
Adjusted (1) |
Adjusted (2) |
||||
---|---|---|---|---|---|---|---|---|
Deaths/PY | Rate (95% CI)/100 PY | RR (95% CI) | P Value | RR (95% CI) | P Value | RR (95% CI) | P Value | |
Overall | 924/151191 | 0.61 (.57, .65) | ||||||
Any cLEE | ||||||||
No | 682/114389 | 0.60 (.55, .64) | Ref. | Ref. | Ref. | |||
Yes | 242/36802 | 0.66 (.57, .74) | 1.10 (.95, 1.28) | .19 | 1.13 (.97, 1.32) | .11 | 1.15 (.99, 1.34) | .08 |
No. of episodes of cLEE | ||||||||
None | 682/114389 | 0.60 (.55, .64) | ||||||
1 | 192/28835 | 0.67 (.57, .76) | ||||||
2 | 41/6539 | 0.62 (.43, .82) | ||||||
3 | 9/1168 | 0.77 (.35, 1.46) | ||||||
≥4 | 0/230 | 0 (, 1.60) | ||||||
Per cLEE | 1.05 (.95, 1.17) | .35 | 1.06 (.96, 1.18) | .25 | 1.07 (.96, 1.19) | .20 | ||
Total duration of cLEE, years | ||||||||
≤0.5 | 685/117583 | 0.58 (.54, .63) | ||||||
>0.5–1 | 90/13227 | 0.68 (.54, .82) | ||||||
>1–1.5 | 40/5745 | 0.70 (.48, .91) | ||||||
>1.5–2 | 30/3935 | 0.76 (.49, 1.04) | ||||||
>2–3 | 51/4566 | 1.12 (.81, 1.42) | ||||||
>3–4 | 18/2527 | 0.71 (.42, 1.13) | ||||||
>4 | 10/3609 | 0.28 (.13, .51) | ||||||
Per year | 1.02 (.96, 1.07) | .61 | 1.01 (.95, 1.07) | .76 | 1.01 (.96, 1.07) | .67 |
Abbreviations: CI, confidence interval; cLEE, chronic liver enzyme elevation; HIV, human immunodeficiency virus; PY, patient years; Ref., reference; RR, rate ratio.
a Adjusted for (1) sex, age, ethnicity, mode of HIV acquisition, body mass index, smoking status, calendar year, and participating cohort, and (2) additionally for the latest CD4 cell count and HIV RNA value.