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. 2016 Jan 21;3(1):ofw009. doi: 10.1093/ofid/ofw009

Table 2.

Associations between cLEE, number of Episodes of cLEE, Total Duration of cLEE, and All-Cause Mortalitya

Events All-Cause Mortality
Unadjusted
Adjusted (1)
Adjusted (2)
Deaths/PY Rate (95% CI)/100 PY RR (95% CI) P Value RR (95% CI) P Value RR (95% CI) P Value
Overall 924/151191 0.61 (.57, .65)
Any cLEE
 No 682/114389 0.60 (.55, .64) Ref. Ref. Ref.
 Yes 242/36802 0.66 (.57, .74) 1.10 (.95, 1.28) .19 1.13 (.97, 1.32) .11 1.15 (.99, 1.34) .08
No. of episodes of cLEE
 None 682/114389 0.60 (.55, .64)
  1 192/28835 0.67 (.57, .76)
  2 41/6539 0.62 (.43, .82)
  3 9/1168 0.77 (.35, 1.46)
  ≥4 0/230 0 (, 1.60)
 Per cLEE 1.05 (.95, 1.17) .35 1.06 (.96, 1.18) .25 1.07 (.96, 1.19) .20
Total duration of cLEE, years
 ≤0.5 685/117583 0.58 (.54, .63)
 >0.5–1 90/13227 0.68 (.54, .82)
 >1–1.5 40/5745 0.70 (.48, .91)
 >1.5–2 30/3935 0.76 (.49, 1.04)
 >2–3 51/4566 1.12 (.81, 1.42)
 >3–4 18/2527 0.71 (.42, 1.13)
 >4 10/3609 0.28 (.13, .51)
 Per year 1.02 (.96, 1.07) .61 1.01 (.95, 1.07) .76 1.01 (.96, 1.07) .67

Abbreviations: CI, confidence interval; cLEE, chronic liver enzyme elevation; HIV, human immunodeficiency virus; PY, patient years; Ref., reference; RR, rate ratio.

a Adjusted for (1) sex, age, ethnicity, mode of HIV acquisition, body mass index, smoking status, calendar year, and participating cohort, and (2) additionally for the latest CD4 cell count and HIV RNA value.