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. 2016 Feb 25;11(2):e0148480. doi: 10.1371/journal.pone.0148480

Fig 1. The expression of miR-99a and mTOR in heart with hypertrophy and failure induced by TAC in mice.

Fig 1

A. Representative images of hearts. B-D. UCG measurement after TAC surgery. There was no significant difference in EF% and LVID;d between sham and TAC group 1 week after surgery (concentric hypertrophy). Decreased EF% and enlarged LVID;d were observed in TAC group 8 weeks after surgery (eccentric hypertrophy). IVS;d was increased both 1 week and 8 weeks after surgery. E-F. mTOR expression was increased 1 week and 8 weeks after TAC. G-H. MiR-99a expression was increased 1 week after surgery, but low correlated with cardiac function. I-J. MiR-99a expression was increased 8 weeks after surgery, and showed a high correlated with cardiac function. (1 week after TAC: n = 11; 8 weeks after TAC: n = 16; Sham group: n = 6). *, p<0.05.