TABLE 1.

MicroRNAs are shown to modulate the expression of Phase I and II drug-metabolizing enzymes

Enzyme	miRNA	Experimental Methods	References
CYP1A1	miR-892a	Reporter assay, mRNA and protein expression, and functional assay	Choi et al., 2012
CYP1B1	miR-27b	Correlation, reporter assay, protein expression, and functional assay	Tsuchiya et al., 2006
		Protein and mRNA expression	Chuturgoon et al., 2014
CYP2C8	miR-103, miR-107	Reporter assay, mRNA and protein expression, and correlation analysis	Zhang et al., 2012
CYP2C9	miR-128-3p	RNA electrophoresis mobility shift assay, reporter assay, mRNA & protein expression and correlation	Yu et al., 2015a
	miR-130b	Reporter assay, protein expression, and function	Rieger et al., 2015
	miR-103 & miR-107	Protein expression	Zhang et al., 2012
CYP2C19	miR-103 & miR-107	Protein expression	Zhang et al., 2012
	miR-29a-3p	RNA electrophoresis mobility shift assay, mRNA & protein expression, correlation	Yu et al., 2015c
CYP2E1	miR-378	Reporter assay, mRNA & protein expression, correlation, and functional assay	Mohri et al., 2010
	miR-570	Reporter assay, mRNA & protein expression, and correlation study	Nakano et al., 2015
CYP2J2	let-7b	Reporter assay, protein expression, and functional assay	Chen et al., 2012a
CYP3A4	miR-27b	Reporter assay, mRNA and protein expression, and functional assay	Pan et al., 2009a; Li et al., 2014b
	miR-34a	Correlation	Lamba et al., 2014
	miR-577, -1, -532-3p, -627	Correlation, reporter assay	Wei et al., 2014b
CYP24A1	miR-125b	Reporter assay, mRNA & protein expression, and functional assay	Komagata et al., 2009
UGT1A1/1A3/1A6	miR-491-3p	Reporter assay, mRNA expression, correlation and/or activity	Dluzen et al., 2014
UGT2B15 & 2B17	miR-376c	Reporter assay, mRNA expression and enzymatic activity	Wijayakumara et al., 2015
GSTπ	miR-130b	mRNA and protein expression	Zong et al., 2014
SULT1A1	miR-631	Reporter assay, mRNA and protein expression	Yu et al., 2010