TABLE 2.
MicroRNAs are revealed to control the expression of efflux and uptake drug transporters
| Transporter | miRNA | Experimental Methods | References |
|---|---|---|---|
| ABCB1/P-gp | let-7g | mRNA and protein expression, functional assay, and correlation | Boyerinas et al., 2012 |
| miR-9 | Protein expression and functions (increase) | Munoz et al., 2013 | |
| miR-19a/b | mRNA and protein expression, functional assay (signal transduction) | Wang et al., 2013 | |
| miR-21 | Protein expression and functions (increase) | Xie et al., 2013; Dong et al., 2015 | |
| miR-27a | mRNA and protein expression, and functional assay (increase) | Zhu et al., 2008; Li et al., 2010c | |
| Reporter assay, mRNA/protein expression, and function (increase; promoter?) | Zhang et al., 2010 | ||
| Reporter assay, protein expression, and function | Feng et al., 2011 | ||
| mRNA/protein expression, and function (decrease; via Frizzled Class Receptor 7/β-catenin) | Chen et al., 2013 | ||
| miR-129-5p | Reporter assay, protein expression, and function | Wu et al., 2014 | |
| miR-130a | mRNA and protein expression, and function (increase) | Yang et al., 2012 | |
| miR-130b | mRNA and protein expression, and function (increase) | Zong et al., 2014 | |
| miR-137 | Protein expression (probably via Y-box binding protein-1) | Zhu et al., 2013 | |
| miR-138 | mRNA and protein expression and function (indirect effects?) | Zhao et al., 2010 | |
| miR-145 | Reporter assay, protein expression and function | Ikemura et al., 2013; Zhu et al., 2014 | |
| miR-200c | mRNA and protein expression, and function | Chen et al., 2012c | |
| mRNA and protein expression (via Polycomb complex protein BMI-1) | Liu et al., 2012 | ||
| miR-223 | Reporter assay, mRNA/protein expression, and functional assay | Yang et al., 2013 | |
| miR-296 | Reporter assay, mRNA/protein expression, and function (increase; promoter?) | Hong et al., 2010 | |
| miR-298 | Reporter assay, protein expression and function | Bao et al., 2012 | |
| miR-331-5p | Reporter assay, protein expression, and function | Feng et al., 2011 | |
| miR-381 & -495 | Reporter assay, protein expression, and function | Xu et al., 2013 | |
| miR-451 | Reporter assay, mRNA and protein expression, and function | Kovalchuk et al., 2008 | |
| mRNA and protein expression, and functional assay (increase) | Zhu et al., 2008 | ||
| mRNA and protein expression, and function | Bitarte et al., 2011 | ||
| miR-508-5p | Reporter assay, mRNA and protein expression, and functional assays | Shang et al., 2014 | |
| ABCB9 | miR-31 | Reporter assay; mRNA expression; protein expression and function | Dong et al., 2014 |
| ABCG2/BCRP | miR-142-3p | Reporter assay, mRNA and protein expression, and functional assays | Shen et al., 2013 |
| miR-145 | Reporter assay, mRNA and protein expression, and functional assays | Shi et al., 2014c | |
| miR-181a | Reporter assay, mRNA and protein expression, and functional assays | Jiao et al., 2013 | |
| miR-200c | mRNA and protein expression (via Polycomb complex protein BMI-1) | Liu et al., 2012 | |
| miR-212 | Reporter assay, protein expression | Turrini et al., 2012 | |
| miR-328 | Reporter assay, mRNA and protein expression, and functional assays | Pan et al., 2009g; Li et al., 2011; Xu et al., 2012c | |
| miR-487a | Reporter assay, mRNA and protein expression, and functional assays | Ma et al., 2013 | |
| miR-519c | Reporter assay, mRNA and protein expression, and functional assays | To et al., 2008, 2009; Li et al., 2011 | |
| miR-520h | Reporter assay, mRNA and protein expression | Liao et al., 2008; Wang et al., 2010; Li et al., 2011 | |
| ABCC1/MRP1 | miR-7 | Reporter assay, mRNA and protein expression, and association study | Liu et al., 2015 |
| miR-133a | Reporter assay, mRNA and protein expression, and functional assays | Ma et al., 2015 | |
| miR-134 | mRNA and protein expression | Guo et al., 2010 | |
| miR-326 | Reporter assay, mRNA and protein expression, and functional assays | Liang et al., 2010; Ma et al., 2015 | |
| miR-1291 | Reporter assay, mRNA and protein expression, and functional assays | Pan et al., 2013; Li et al., 2015 | |
| ABCC2/MRP2 | let-7c | Reporter assay, mRNA and protein expression, and functional assay | Zhan et al., 2013 |
| miR-297 | Reporter assay, mRNA and protein expression, and functional assay | Xu et al., 2012a | |
| miR-379 | Reporter assay, mRNA and protein expression, and functional assays | Haenisch et al., 2011; Werk et al., 2014 | |
| ABCC4/MRP4 | miR-124a & miR-506 | Reporter assays, mRNA and protein expression, functional assay, and correlation study | Markova and Kroetz, 2014 |
| ABCC5/MRP5 | miR-128 | Reporter assay, protein expression, and functional assay | Zhu et al., 2011 |
| Li et al., 2014a | |||
| miR-129-5p | Reporter assay, mRNA & protein expression, and function | Wu et al., 2014 | |
| ABCE1 | miR-203 | Reporter assay and protein expression | Furuta et al., 2010 |
| SLC15A1/PEPT1 | miR-92b | Reporter assay, mRNA and protein expression, and functional assays | Dalmasso et al., 2011 |
| miR-193-3p | Correlation study, mRNA and protein expression, and functional assays | Dai et al., 2015 | |
| SLC16A1/MCT1 | miR-124 | Reporter assay, protein expression and function | Li et al., 2009 |
| miR-29a/b & -124 | Reporter assay, mRNA and protein expression | Pullen et al., 2011 |