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Effect of DHM and DHK on coumarin 7-hydroxylation (CYP2A5) activity in mouse liver microsomes
Mouse liver microsomes were incubated with 2 µM coumarin and NADPH for 15 minutes at 37°C in the presence or absence of DHM or DHK, which were dissolved in methanol. Hence, 0.4% methanol was added to the control reactions.
| Concentration (µM) | Percentage of Inhibitiona | |
|---|---|---|
| DHK | 10 | 62 ± 6 |
| DHM | 10 | 19 ± 9 |
| DHM | 100 | 71 ± 10 |
Average of three independent experiments performed in duplicate.
