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Effect of dietary DHM and DHK on coumarin 7-hydroxylation (CYP2A5) activity in mouse liver microsomes (n = 3)
Mouse liver microsomes (20–80 µg protein) were incubated with 20 µM coumarin and NADPH for 15 minutes at 37°C.
| 7-Hydroxycoumarin Formationa |
|
|---|---|
| pmol/min/mg | |
| Control | 12 ± 3 |
| DHK (1 mg/g of diet) | 16 ± 4 |
| DHM (1 mg/g of diet) | 17 ± 4 |
Statistical analysis was performed with one-way analysis of variance. None of the differences were statistically significant.
