Fig. 4.

Colchicine impairs axonal transport in primary cortical neurons after 1 hour of exposure. (A) Velocities of APP containing MBOs in the anterograde and retrograde direction; n (moving events) = 116. (B–D) Percentage of mobile (anterograde or retrograde) and stationary APP particles in segments of control and colchicine-treated axons; n (axonal segments) = 38. Each bar represents the mean ± S.E.M. from four independent experiments and four to five replicates per concentration. *P < 0.05 compared with vehicle control conditions.