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. 2016 Mar;356(3):596–603. doi: 10.1124/jpet.115.229997

Fig. 6.

Fig. 6.

Comparison of effects of the GRPR antagonist RC-3095 and NPRA antagonist A71915 on intradermal pruritogen-induced scratching. Each antagonist was intrathecally administered 10 minutes prior to intradermal pruritogen. Scratching bouts were observed immediately after intradermal administration of endothelin (A, B), U-46619 (C, D), BAM8-22 (E, F), or SLIGRL (G, H) up to 30 minutes. Time course in 10-minute intervals (tops: A, C, E, G) and total scratching bouts for 30 minutes (bottoms: B, D, F, H) are shown. Each value represents mean ± S.E.M. (n = 6). #P < 0.05 versus vehicle/SLIGRL.