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Neither A1AR nor A3AR is required for the AR-mediated vasorelaxation in PAs. (A) CRC to NECA, CCPA and Cl-IBMECA in A2A/A2BAR DKO mice. (B) CRC to CCPA in A2A/A2BAR DKO mice in the presence of vehicle or the A1AR antagonist DPCPX (0.1 μM) and the A3AR antagonist MRS1523 (1 μM). (C) CRC to Cl-IBMECA in A2A/A2BAR DKO mice in the presence of vehicle or DPCPX and MRS1523. Data are represented as mean ± S.E.M. (N = 5–8). *P < 0.05 versus NECA.
