Fig. 5.

Effects of R(−)-MDPV, S(+)-MDPV, and MDPV on core temperature at an ambient temperature of 20°C (left) or 28°C (right) in mice. On the abscissae, SAL represents saline administration and numbers refer to doses of drug, expressed as milligram/kilogram on a log scale. The ordinate shows the mean maximum change in core temperature from baseline values over 6 hours postinjection, via radiotelemetry. Asterisks indicate significant differences between dose of drug administered and saline. Hash marks indicate significant differences compared with the effect observed at the same dose administered at 20°C. Errors bars depict means ± S.E.M. IP, intraperitoneally.