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. 2016 Mar;89(3):323–334. doi: 10.1124/mol.115.101758

Fig. 4.

Fig. 4.

Regulation of endogenous Kv7 currents in mesenteric artery myocytes by isoproterenol, rolipram, and forskolin/IBMX. (A) Current-voltage (I-V) relationships of endogenous Kv7 currents recorded in MASMCs before (control, solid circles) and after 5 minute treatment with 1 μM isoproterenol (open circles, n = 6). (B) I-V relationships of endogenous Kv7 currents recorded in MASMCs before (control, solid circles) and after 5 minutes of treatment with 100 nM rolipram (open circles, n = 5), followed by application of ML213 (10 μM, open triangles, n = 5) and 10 μM XE991 in the presence of 10 μM ML213 (solid triangles, n = 4). The asterisks (*) indicate significant difference from control, P < 0.05, one-way repeated-measures analysis of variance. (C) I-V relationships of endogenous Kv7 currents recorded in MASMCs before (control, solid circles) and after 5 minutes of treatment with 1 μM forskolin in the presence of 500 μM IBMX (open circles, n = 5, * indicates significant difference from control, P < 0.05, paired Student’s t test) and after 10 minutes of washout (solid upward triangles), followed by application of 1 μM XE991 (solid downward triangles, n = 4).