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. 2016 Feb 25;11(2):e0148659. doi: 10.1371/journal.pone.0148659

Table 2. Correlation between CTCs status before (CTC1) and after surgery (CTC2) and clinicopathological characteristics.

  CTC1 CTC2
N(%) + N(%) - p N(%) + N(%) - p
Age (years) < 70 13 (41.9%) 18 (58.1%) 0.116 11 (35.5%) 20 (64.5%) 0.58
≥ 70 16 (64%) 9 (36%) 7 (28%) 18 (72%)
Gender Male 27 (54%) 23 (46%) 0.301 17 (34%) 33 (66%) 0.363
Female 2 (33.3%) 4 (66.7%) 1 (16.7%) 5 (83.3%)
p TNM Stage I 13 (50%) 13 (50%) 0.508 7 (26.9%) 19 (73.1%) 0.313
II-III 16 (53.3%) 14 (46.7%) 11 (36.7%) 19 (63.3%)
Nodal status N0 21 (48.8%) 22 (51.2%) 0.315 14 (32.6%) 29 (67.4%) 0.594
N1-N2 8 (61.5%) 5 (38.5%) 4 (30.8%) 9 (69.2%)
Tumor size < 3 13 (56.5%) 10 (43.5%) 0.375 7 (30.4%) 16 (69.6%) 0.527
(cm) ≥ 3 16 (48.5%) 17 (51.5%) 11 (33.3%) 22 (66.7%)
PET < 7 7 (63.6%) 4 (36.4%) 0.380 4 (36.4%) 7 (63.6%) 0.738
(max SUV value)
≥ 7 22 (48.9%) 23 (51.1%) 14 (31.1%) 31 (68.9%)
Histology Adenocarcinoma 11 (44%) 14 (56%) 0.218 8 (32%) 17 (68%) 0.606
Other 18 (58.1%) 13 (41.9%) 10 (32.3%) 21 (67.7%)
Surgical approach Thoracotomy 18 (50%) 18 (50%) 0.469 12 (33.3%) 24 (66.7%) 0.521
VATS 11 (55%) 9 (45%) 6 (30%) 14 (70%)  
Type of ressection Pneumonectomy 4 (50%) 4 (50%) 0.605 0 (0%) 8 (100%) 0.034
Other 25 (52.1%) 23 (47.9%) 18 (37.5%) 30 (62.5%)

(N: Number of patients)