Figure 2.

Primary sequence alignment of the Ftp enzyme active center based on the Ftp_Tp structure. The numbering is based on Ftp_Tp, and the active‐site residues are highlighted in colors. Indicated in blue lettering are the names of the Mg²⁺‐dependent FAD pyrophosphatase Ftps, and in red lettering are the names of the FAD binding Ftps. Listed above the sequence in red letters are the residues involved in either metal or FAD binding in the Ftps; underlined is the critical residue that contacts the isoalloxazine ring of FAD, which is a tyrosine residue in the FAD‐binding Ftps.