Table 1. Important and selected copy number alterations in LPS cell lines relevant to transformation.
| Cell Line(s) | Alteration | Chromosome | Selected Gene(s) |
|---|---|---|---|
| SW872 | HD | 10q23.31 | PTEN |
| T1000, T778 | AMP | 4p15.2 | PPARGC1A |
| LPS141 | HD | 9p23 | PTPRD |
| MLS402 | HD | 3p14.2 | FHIT |
| MLS402 | UPD | 13q14.2-14.3 | RB1, SETDB2, RCBTB1, DLEU2, MIR15-A, MIR16-1, |
| T778, FU-DDLS-1, LP6, MLS402 | AMP | 5p15.33 | TERT |
| FU-DDLS-1, MLS402, LPS141, | AMP | 5p15.2 | CTNND2 |
| MLS402 | AMP | 11q22 | YAP1, BIRC2, BIRC3 |
| MLS402 | AMP | 14q22.2 | CDKN3 |
| LiSa-2 | AMP | 19q13 | PAK4, AKT2 |
| LiSa-2 | HD | 13q | RB1, SETDB2, RCBTB1, DLEU2, MIR15-A, MIR16-1, |
| LiSa-2 | HD | 3p24 | RBMS3 |
| GOT-3 | HD | 9q33.1 | DEC1 |
| LPS141, GOT-3 | HD | 16q23 | WWOX |
| GOT-3 | AMP | Xp22.31 | PNPLA4 |
| LPS1, LPS2, LPS3, SA4, | HD | 9p21.3 | CDKN2A, CDKN2B |
| SA4 | HD | 10p14 | GATA3 |
| SA4 | HD | 10p11.21 | PARD3 |
| SA4 | HD | 15q15.3 | TP53BP1 |
| LiSa-2 | HD | 16q12.2 | RBL2, CYLD, SALL1, SIAH |
| FU-DDLS-1, LPS1, LPS2, LPS3, LP6 | AMP | 1p32.1 | JUN |
HD: homozygous deletion; AMP: amplification; UPD: uniparental disomy