Figure 3. OEA modulated hepatic fibrotic genes expression in MCD diet-induced fibrosis mice by PPAR-α.

The effect of OEA on liver mRNA levels of TGF-β A., α-SMA B., Col1a C., Col3a D., TIMP1 E., MMP-2 F., and MMP-9 G. in wild-type (WT) mice and PPAR-α knockout mice fed with normal diet, MCD diet, MCD diet combined with OEA administration (5 mg/kg/day, i.p.). Data are shown as means ± s.e.m.; n = 6-8 in each group. ^# P < 0.05, ^## P < 0.01, ^### P < 0.001, ^* P < 0.05, ^** P < 0.01.