Table 3. Differentially expressed miRNAs in the validation set determined using qRT-PCR (containing samples used in the selection phase).

	Gene symbol	Rank	Parametric P-value	HCs (n = 70)	RA (n = 75)	Fold-change
Up-regulated	hsa-miR-4634	1	0.0118	10.01	4.358	2.297
	hsa-miR-181d	2	0.0201	4.060	1.686	2.408
	hsa-miR-4764-5 p	3	0.0299	15.12	29.69	1.964
Down-regulated	hsa-miR-342-3p	1	0.0001	2.310	0.5078	0.2198
	hsa-miR-3926	2	0.0001	6.891	1.182	0.1715
	hsa-miR-3925-3p	3	0.0001	0.8896	0.04146	0.04661
	hsa-miR-122-3p	4	0.0207	13.27	2.729	0.2057
	hsa-miR-9-5p	5	0.0223	7.625	21.32	0.2796
	hsa-miR-219-2-3p	6	0.0331	16.18	3.768	0.2329

Ranked by P-values generated from statistical comparisons between RA patients and HCs. In the RA and HCs columns, values for the mean of 2^−Δcq for each group are listed. Fold-change is the ratio of relative expression of RA vs. HCs.