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. 2015 Oct 13;6(40):42667–42686. doi: 10.18632/oncotarget.5626

Figure 6. IL-6 sustains formation of NSCLC LCSs.

Figure 6

A. Effects of anti-IL-6 mAb (3.0 μg/ml) on the formation of secondary LCSs in NCI-H460 and PEd/10 cells. ***p < 0.001; **p < 0.01. B. Effects of IL-6 administration (20 ng/ml) on the formation of secondary LCSs in NCI-H460 and derivatives, PEd/10 and derivatives. **p < 0.01. C. Effects of anti-IL-6-mAb (3.0 μg/ml) or IL-6 administration (20 ng/ml) on the formation of LCSs generated from BEAS-C and BEAS-Akt1-E17K. *p < 0.05. D. Number of LCSs generated from PEd/10 cells or the corresponding cells interfered for IL-6r (PEd/10-shIL-6r; clones #1, #2). ***p < 0.001. E. Analysis by phase-contrast microscopy of size distribution (μm) of LCSs generated from PEd/10-scr and PEd/10-shIL-6r cells, ***p < 0.001. F. Number of LCSs formed from PEd/10-scr and PEd/10-shIL-6r cells during serial passages (n = 5).