Table 4. Uni and multivariate logistic regression models of patient- and disease-related features and pathological complete response after removal of 13 patients whose hormone receptor status changed during neoadjuvant chemotherapy (N:53).
| Univariate logistic regression model (*) | Multivariate logistic regression model (*) | ||||
|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| Age | >48.4 vs ≤48.4 | 3.78 (1.02–14.06) | 0.047 | 4.65 (0.99–21.87) | 0.052 |
| Stage | III vs II | 0.70 (0.19–2.63) | 0.597 | 1.78 (0.30–10.43) | 0.521 |
| Grade | III vs I-II | 1.08 (0.33–3.58) | 0.899 | 1.46 (0.31- 6.84) | 0.627 |
| CT | Conc vs Seq | Not applicable | Not applicable | ||
| Ki-67 | ≥60 vs <60 | 0.35 (0.10–1.19) | 0.092 | 0.25 (0.05–1.19) | 0.082 |
| γ-H2AX | high vs low | 4.71 (1.26–17.66) | 0.021 | 7.07 (1.39–36.02) | 0.018 |
| pChk1 | pos vs neg | 1.40 (0.38–5.10) | 0.610 | 1.10 (0.21–5.67) | 0.909 |
(*)
Type of chemotherapy (concomitant vs sequential) was not included in uni- and multivariate models given that no pCRs were seen in patients treated with a concomitant schedule. Abbreviations, CT: chemotherapy; Conc: concomitant; Seq: sequential.