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. 2015 Oct 26;6(40):42813–42824. doi: 10.18632/oncotarget.5970

Figure 4. LINC00152 activated mTOR via binding the promoter of EpCAM.

Figure 4

A. Different expression of mTOR and p-mTOR in human tissues in LINC00152low and LINC00152high groups. B. Location of LINC00152 and EpCAM in Chromosome 2. C. Correlation expression levels of LINC00152 and EpCAM using Pearson analysis. D. Different RNA expression levels of LINC00152 and EpCAM in cell lines. E. RNA expression level of LINC00152 in cells treated with sh152-1 and control (top panel). Protein expression level of EpCAM in cells treated with sh152-1 and control (lower panel). F. Cells were co-transfected with the promoter region of EpCAM with reporter, the Renilla luciferase vector pRL-SV40 and LINC00152 shRNA, or control for 48 h. Both firefly and Renilla luciferase activities were measured in the same sample. Firefly luciferase signals were normalized with Renilla luciferase signals. Cells treated with controls of miRNA were normalized to 100%.