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. 2015 Oct 19;6(40):42854–42867. doi: 10.18632/oncotarget.5733

Figure 6. Overexpression of HRD1 in breast cancer cells inhibits in vivo tumor growth and metastasis.

Figure 6

MB231 cells stably overexpressing of HRD1 and the corresponding controls were injected into the right flank and left flank of nude mice, respectively. Tumor sizes were monitored twice per week A. and tumor weights B. were measured. C. The expression of HRD1 in tumor lysates was measured. D. MB231 cells stably overexpressing of HRD1 were inoculated into nude mice of via the tail vein. After 5 weeks, the lungs from mice in each experimental group were examined for calculation of the numbers of tumor nodules on lung surfaces. **P < 0.01, compared to vector.