Table 1. Correlation of clinicopathological features of breast cancer with HRD1 expression levels.
Characteristics | All cases | HRD1 expression levels | ||
---|---|---|---|---|
High expression | Low expression | P value | ||
Age | 0.552 | |||
<50 | 86 | 32 | 54 | |
≥50 | 84 | 35 | 49 | |
Tumor size (cm) | 0.225 | |||
<2 | 74 | 33 | 41 | |
≥2 | 96 | 34 | 62 | |
Grade | 0.023* | |||
I, well-differentiated | 23 | 14 | 9 | |
II, moderately differentiated | 99 | 40 | 59 | |
III, poorly differentiated | 48 | 13 | 35 | |
Tumor histological | 0.064 | |||
Ductal carcinoma in situ | 23 | 14 | 9 | |
Invasive ductal carcinoma | 130 | 48 | 82 | |
Invasive lobular carcinoma | 17 | 5 | 12 | |
ER status | 0.989 | |||
Negative | 61 | 24 | 37 | |
Positive | 109 | 43 | 66 | |
PR status | 0.557 | |||
Negative | 79 | 33 | 46 | |
Positive | 91 | 34 | 57 | |
HER2/neu status | 0.776 | |||
Negative | 112 | 45 | 67 | |
Positive | 58 | 22 | 36 | |
IGF-1R status | 0.000* | |||
Negative | 57 | 36 | 21 | |
Positive | 113 | 31 | 82 | |
Lymph node-metastasis | 0.000* | |||
Negative | 90 | 57 | 33 | |
Positive | 80 | 10 | 70 | |
Nuclear p65 expression | ||||
High expression | 60 | 37 | 23 | 0.000* |
Low expression | 110 | 30 | 80 |