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. 2015 Oct 16;6(40):43081–43089. doi: 10.18632/oncotarget.5638

Figure 5. Metastasis-associated genes are involved in the neutrophils-promoting invasion through AR. (a-c.) the expressions.

Figure 5

The expression of MMP1 (a) MMP13 (b) and SYK (c) were upregulated by co-culturing T-24 cells with HL-60N and inhibited by knocking down AR (shAR). (d-e) The expressions of MMP13 d. and HGF e. were up-regulated by co-culturing J82 cells with HL-60N and inhibited by knocking down AR in J82. f. MMP13 expression level of T24 and J82 cells after co-culture with HL-60N for 48 hours using western blot. (g-h.) microscopic images of T24 (g) and J82 (h) cells with and without knocked down MMP13 (shMMP13) and with and without co-culture with neutrophils, quantitations at right. (scale bars = 20 μm) (N: HL-60N). **p < 0,01; ***p < 0.001.