Table 4.

Predicted 5-year breast cancer risk for cases and controls according to the risk models and their corresponding combined risk scores

Risk scores	Combined risk score
	Cases					Controls
	<1.5%	≥1.5% and <2.0%	≥2.0%	Up	Down	<1.5%	≥1.5% and <2.0%	≥2.0%	Up	Down	NRI (95% CI)
BOADICEA				9.1%	13.1%				4.7%	1.0%	0.040 (0.007, 0.073)
<1.5%	614	33	24			377	13	4
≥1.5% and <2.0%	7	3	11			2	3	2
≥2.0%	1	2	55			1	1	2
BRCAPRO				10.7%	0%				4.7%	0.2%	0.063 (0.030, 0.094)
<1.5%	616	50	30			382	15	4
≥1.5% and <2.0%	0	0	0			1	0	0
≥2.0%	0	0	52			0	0	3
BCRAT				14.1%	1.4%				6.8%	0.7%	0.066 (0.019, 0.110)
<1.5%	471	45	24			256	13	4
≥1.5% and <2.0%	8	7	11			2	3	2
≥2.0%	0	0	2			0	0	0
IBIS				10.7%	1.1%				6.2%	1.7%	0.052 (0.015, 0.088)
<1.5%	595	44	23			363	18	4
≥1.5% and <2.0%	5	4	13			4	2	3
≥2.0%	2	1	63			1	2	8

Abbreviations: CI, confidence interval; NRI, net reclassification improvement

Note: Up is a change to a higher risk category and down is a change to a lower risk category.