Table 1.
TWAS significant genes with no known GWAS risk variants within 500Kb.
GWAS | trainingexpression | gene | chr | locus start | locus end | p-value | |||
---|---|---|---|---|---|---|---|---|---|
TWAS | permuted | bestcis-SNP | |||||||
LOCKE.BMI | omnibus | INO80E | 16 | 29506615 | 30517114 | 3E-09 | 3E-07 | 3E-06 | * |
LOCKE.BMI | omnibus | FTSJ3 | 17 | 61396793 | 62407372 | 1E-07 | 5E-06 | 9E-07 | * |
LOCKE.BMI | omnibus | PAM | 5 | 101589685 | 102866809 | 3E-07 | 4E-09 | 3E-03 | * |
LOCKE.BMI | YFS | GGNBP2 | 17 | 34400737 | 35446278 | 1E-06 | 7E-05 | 3E-06 | * |
LOCKE.BMI | YFS | MYO19 | 17 | 34351477 | 35399284 | 3E-06 | 4E-05 | 3E-06 | * |
LOCKE.BMI | omnibus | OPRL1 | 20 | 62211526 | 63231996 | 3E-06 | 9E-05 | 2E-05 | * |
LOCKE.BMI | NTR | RABGAP1 | 9 | 125203287 | 126367145 | 4E-06 | 3E-05 | 1E-05 | * |
LOCKE.BMI | YFS | SMARCD2 | 17 | 61409444 | 62420425 | 5E-06 | 9E-05 | 9E-07 | * |
LOCKE.BMI | METSIM | AL049840.1 | 14 | 103677607 | 104679149 | 5E-06 | 5E-05 | 1E-07 | * |
LOCKE.BMI | omnibus | LPAR2 | 19 | 19234477 | 20239739 | 6E-06 | 3E-05 | 4E-06 | * |
WILLER.HDL | YFS | MRPS18B | 6 | 30085486 | 31094172 | 1E-07 | 2E-02 | 4E-06 | |
WILLER.LDL | omnibus | PAM | 5 | 101589685 | 102866809 | 4E-15 | 9E-12 | 2E-03 | * |
WILLER.LDL | omnibus | ITIH4 | 3 | 52346991 | 53365495 | 8E-09 | 4E-06 | 3E-05 | * |
WILLER.LDL | omnibus | WARS | 14 | 100300125 | 101343142 | 1E-08 | 6E-07 | 3E-05 | * |
WILLER.LDL | omnibus | MAN2C1 | 15 | 75148133 | 76160971 | 1E-08 | 1E-05 | 6E-05 | * |
WILLER.LDL | YFS | DHRS13 | 17 | 26724799 | 27730089 | 6E-07 | 4E-04 | 2E-06 | * |
WILLER.LDL | YFS | ERAL1 | 17 | 26681956 | 27688085 | 8E-07 | 9E-04 | 2E-06 | |
WILLER.LDL | YFS | HCG27 | 6 | 30665537 | 31671745 | 2E-06 | 7E-03 | 7E-08 | |
WILLER.LDL | YFS | VARS2 | 6 | 30376019 | 31394236 | 3E-06 | 2E-02 | 1E-05 | |
WILLER.LDL | omnibus | PEX6 | 6 | 42431608 | 43446958 | 5E-06 | 3E-05 | 4E-04 | * |
WILLER.LDL | omnibus | CSK | 15 | 74574398 | 75595539 | 6E-06 | 1E-04 | 1E-05 | * |
WILLER.TC | omnibus | PAM | 5 | 101589685 | 102866809 | 9E-15 | 3E-13 | 5E-03 | * |
WILLER.TC | omnibus | WARS | 14 | 100300125 | 101343142 | 2E-08 | 4E-06 | 2E-05 | * |
WILLER.TC | omnibus | MAN2C1 | 15 | 75148133 | 76160971 | 3E-07 | 7E-05 | 2E-06 | * |
WILLER.TC | omnibus | ITIH4 | 3 | 52346991 | 53365495 | 6E-07 | 2E-05 | 5E-05 | * |
WILLER.TC | NTR | CDK2AP1 | 12 | 123245552 | 124256687 | 6E-07 | 2E-04 | 5E-06 | * |
WILLER.TC | YFS | TBKBP1 | 17 | 45271447 | 46289416 | 9E-07 | 3E-04 | 2E-07 | * |
WILLER.TC | METSIM | RPP25 | 15 | 74746757 | 75749805 | 2E-06 | 2E-04 | 9E-07 | * |
WILLER.TC | omnibus | CSK | 15 | 74574398 | 75595539 | 2E-06 | 9E-05 | 9E-07 | * |
WILLER.TC | YFS | MPI | 15 | 74682346 | 75691798 | 2E-06 | 2E-04 | 5E-06 | * |
WILLER.TC | omnibus | DAGLB | 7 | 5948757 | 7023821 | 2E-06 | 8E-05 | 7E-06 | * |
WILLER.TC | NTR | TOM1 | 22 | 35195267 | 36243985 | 2E-06 | 2E-06 | 1E-06 | * |
WILLER.TC | METSIM | HMGXB4 | 22 | 35153445 | 36191800 | 3E-06 | 4E-05 | 4E-07 | * |
WILLER.TC | NTR | C17orf68 | 17 | 7628139 | 8651413 | 3E-06 | 6E-06 | 2E-07 | * |
WILLER.TG | YFS | PABPC4 | 1 | 39526488 | 40542462 | 1E-08 | 1E-04 | 8E-08 | * |
WILLER.TG | omnibus | PACS1 | 11 | 65337834 | 66512218 | 5E-08 | 3E-04 | 1E-05 | * |
WOOD.HEIGHT | omnibus | INO80E | 16 | 29506615 | 30517114 | 2E-10 | 2E-05 | 1E-07 | * |
WOOD.HEIGHT | NTR | INPP5B | 1 | 37825435 | 38912729 | 2E-09 | 1E-06 | 1E-06 | * |
WOOD.HEIGHT | omnibus | MEGF9 | 9 | 122863091 | 123976748 | 3E-09 | 2E-04 | 1E-07 | * |
WOOD.HEIGHT | omnibus | ATF1 | 12 | 50657493 | 51714905 | 6E-09 | 4E-05 | 1E-06 | * |
WOOD.HEIGHT | omnibus | PAM | 5 | 101589685 | 102866809 | 2E-08 | 8E-06 | 1E-05 | * |
WOOD.HEIGHT | omnibus | CNIH4 | 1 | 224044552 | 225067161 | 3E-08 | 2E-05 | 6E-08 | * |
WOOD.HEIGHT | omnibus | PLEKHA1 | 10 | 123634212 | 124691867 | 1E-07 | 3E-05 | 6E-07 | * |
WOOD.HEIGHT | NTR | PDXDC1 | 16 | 14568832 | 15632186 | 1E-07 | 3E-03 | 7E-06 | |
WOOD.HEIGHT | YFS | MSRB2 | 10 | 22884435 | 23910942 | 2E-07 | 2E-04 | 3E-06 | * |
WOOD.HEIGHT | YFS | ZNF213 | 16 | 2679778 | 3692806 | 2E-07 | 1E-03 | 6E-07 | |
WOOD.HEIGHT | NTR | YWHAB | 20 | 43014185 | 44037354 | 5E-07 | 3E-04 | 4E-06 | * |
WOOD.HEIGHT | NTR | ITM2B | 13 | 48307273 | 49336451 | 5E-07 | 4E-05 | 1E-06 | * |
WOOD.HEIGHT | omnibus | WDSUB1 | 2 | 159592304 | 160643310 | 7E-07 | 3E-04 | 5E-06 | * |
WOOD.HEIGHT | NTR | STAT6 | 12 | 56989190 | 58005129 | 8E-07 | 3E-03 | 8E-06 | |
WOOD.HEIGHT | omnibus | PLCL1 | 2 | 198169426 | 199937305 | 9E-07 | 4E-03 | 6E-07 | |
WOOD.HEIGHT | YFS | H2AFJ | 12 | 14427270 | 15430936 | 1E-06 | 4E-04 | 6E-07 | * |
WOOD.HEIGHT | YFS | FAM8A1 | 6 | 17100586 | 18111950 | 1E-06 | 2E-03 | 1E-07 | |
WOOD.HEIGHT | METSIM | AC016995.3 | 2 | 38133861 | 39242882 | 1E-06 | 3E-04 | 4E-05 | * |
WOOD.HEIGHT | omnibus | CDA | 1 | 20415441 | 21445401 | 1E-06 | 3E-04 | 6E-07 | * |
WOOD.HEIGHT | YFS | ECHDC2 | 1 | 52861656 | 53892884 | 1E-06 | 3E-03 | 1E-05 | |
WOOD.HEIGHT | YFS | NFATC3 | 16 | 67618654 | 68763162 | 2E-06 | 4E-03 | 4E-07 | |
WOOD.HEIGHT | YFS | SH3YL1 | 2 | −282270 | 766398 | 2E-06 | 1E-04 | 6E-07 | * |
WOOD.HEIGHT | omnibus | PABPC4 | 1 | 39526488 | 40542462 | 3E-06 | 4E-04 | 6E-06 | * |
WOOD.HEIGHT | METSIM | RP11-473M20.14 | 16 | 2666043 | 3684883 | 3E-06 | 4E-03 | 1E-07 | |
WOOD.HEIGHT | omnibus | HEBP1 | 12 | 12627798 | 13653207 | 3E-06 | 7E-04 | 1E-06 | * |
WOOD.HEIGHT | YFS | KBTBD2 | 7 | 32407784 | 33433743 | 3E-06 | 4E-03 | 1E-07 | |
WOOD.HEIGHT | METSIM | LRRC69 | 8 | 91614060 | 92731464 | 3E-06 | 6E-04 | 6E-07 | * |
WOOD.HEIGHT | YFS | RAB23 | 6 | 56553607 | 57587078 | 4E-06 | 4E-03 | 6E-07 | |
WOOD.HEIGHT | YFS | PPP4C | 16 | 29587299 | 30596698 | 5E-06 | 1E-03 | 1E-07 | |
WOOD.HEIGHT | NTR | B3GALNT2 | 1 | 235110442 | 236167884 | 5E-06 | 5E-04 | 1E-06 | * |
WOOD.HEIGHT | YFS | PSRC1 | 1 | 109322178 | 110325808 | 5E-06 | 3E-04 | 1E-07 | * |
WOOD.HEIGHT | YFS | ACSS1 | 20 | 24486868 | 25539616 | 5E-06 | 6E-04 | 1E-06 | * |
WOOD.HEIGHT | omnibus | GGPS1 | 1 | 234990665 | 236007847 | 5E-06 | 4E-04 | 3E-07 | * |
Significant after permutation