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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jan 7;36(3):501–509. doi: 10.1161/ATVBAHA.115.306885

Figure 1.

Figure 1

Original recording of coronary blood flow, measured following coronary artery injury + stenosis, for one representative dog treated with GLS-409. Before randomization and treatment, the animal displayed cyclic variations in coronary flow (CFVs) caused by the repeated, spontaneous accumulation/dislodgment of platelet-rich thrombi at the site of injury + stenosis. Administration of GLS-409 (bolus + infusion denoted by the red arrow + line) was associated with an attenuation in the development of CFVs and better maintenance of coronary patency.