Table 2.
IC50s and 95% confidence intervals for adenosine diphosphate (ADP)-, collagen-, and thrombin receptor-activating peptide (TRAP)-stimulated maximal platelet aggregation with GLS-409, MRS 2179, cangrelor and the combination of cangrelor with 5µM MRS 2179 in platelet-rich plasma from healthy donors prior to and 2 hours after the intake of 325 mg aspirin.
| no aspirin | 2 hours post aspirin | |||||
|---|---|---|---|---|---|---|
| Agent | ADP | Collagen | TRAP | ADP | collagen | TRAP |
| GLS-409 (nM) | 5.5 4.8 – 6.2 |
6.2 5 – 7.6 |
23.9 11.1 – 51.4 |
5.9 5 – 6.9 |
6.1 3.8 – 9.7 |
12.8 8.3 – 19.7 |
| MRS 2179 (µM) | 7.5 1.4 – 39.6 |
indefinable indefinable |
indefinable indefinable |
3.8 1.9 – 7.7 |
5.3 1.7 – 16.3 |
indefinable indefinable |
| cangrelor (nM) | 14.7 12.2 – 17.8 |
18.9 12.7 – 28 |
86.6 7.9 – 943.9 |
15.8 12.8 – 19.5 |
10.1 7.6 – 13.4 |
57.7 16.5 – 201.9 |
| cangrelor + MRS 2179 (nM) | 4.7 3.6 – 6.2 |
4.8 3.4 – 6.6 |
30.9 18.2 – 52.5 |
4.9 4.3 – 5.6 |
4.5 3.7 – 5.5 |
22.4 14 – 35.7 |