Table 4.
IC50s for adenosine diphosphate (ADP)- and thrombin receptor-activating peptide (TRAP)-stimulated maximal platelet aggregation with GLS-409, MRS 2179 and cangrelor in whole blood from healthy donors prior to and 2 hours after the intake of 325 mg aspirin.
| no aspirin | 2 hours post aspirin | |||
|---|---|---|---|---|
| Agent | ADP | TRAP | ADP | TRAP |
| GLS-409 (nM) | 1.6 1.1 – 2.3 |
7.1 2.9 – 17.3 |
2 1.3 – 3.1 |
4.1 2.6 – 6.5 |
| MRS 2179 (µM) | 8 5.5 – 11.5 |
indefinable indefinable |
6.9 3.9 – 12.2 |
Indefinable indefinable |
| cangrelor (nM) | 7.4 4.8 – 11.3 |
3.7 indefinable |
5.3 3.6 – 7.7 |
20.9 8.5 – 51.4 |