Table 2.
Stage 1: association of loci with plasma PAI-1 levels
| Locus | Gene | Counts | Mean PAI-1 | P value |
|---|---|---|---|---|
| *rs4149338 T/C | ATP-Binding Cassette 1 | 23; 98; 106 | 190.2; 146.0; 97.9 | 0.0001 |
| *rs30008 T/C | CD37 Molecule | 17; 74; 136 | 273.8; 122.3; 112.9 | 0.0001 |
| *rs3168046 A/G | Toll Interacting Protein | 34; 126; 67 | 212.6; 115.3; 109.0 | 0.0001 |
| *rs866223 A/G | Mitogen-Activated Protein Kinase Kinase Kinase 1 | 35; 93; 99 | 208.6; 121.7; 105.5 | 0.0001 |
| *rs832573 T/C | Mitogen-Activated Protein Kinase Kinase Kinase 1 | 20; 95; 112 | 245.0; 129.0; 106.3 | 0.0002 |
| rs3793965 T/C | Toll Interacting Protein | 34; 125; 68 | 212.6; 114.2; 111.0 | 0.0002 |
| rs33328 A/G | Mitogen-Activated Protein Kinase Kinase Kinase 1 | 34; 93; 100 | 208.0; 122.2; 106.2 | 0.0002 |
| rs354022 G/A | CD37 Molecule | 17; 77; 133 | 273.8; 120.1; 114.0 | 0.0002 |
| rs832577 G/A | Mitogen-Activated Protein Kinase Kinase Kinase 1 | 34; 95; 97 | 208.0; 122.3; 105.7 | 0.0003 |
| rs832552 G/T | Mitogen-Activated Protein Kinase Kinase Kinase 1 | 41; 90; 92 | 194.2; 125.1; 102.8 | 0.0003 |
| *rs10195871 T/C | B-Cell CLL/Lymphoma 11A (Zinc Finger Protein) | 34; 88; 105 | 83.9; 108.2; 158.9 | 0.0003 |
Locus column displays genotype categorized as heterozygous for the minor allele and major allele displayed in that order. Counts and means columns display number and mean plasma level in each genotype category (minor/minor; minor/major; major/major). Loci associated with PAI-1 plasma levels at P < 10−4 are displayed by additive model P value risk adjusted for recipient age, use of cardiopulmonary bypass, diagnosis, and population admixture.
denotes loci carried forward to stage 2. Loci not marked with an asterisk were in strong linkage disequilibrium with respective loci carried forward. We considered loci with a pairwise linkage disequilibrium R2 ≥ 0.9 in the CEPH HapMap population to indicate the same association signal.