Table 3.

Stage 2: association of selected loci with PGD^*

Locus	Risk/Ref alleles	RAF no PGD	RAF PGD	OR (95%CI)	P value	Gene	Location
rs3168046	A/G	0.44	0.51	1.42 (1.11; 1.83)	0.0061	TOLLIP	3′UTR
rs30008	T/C	0.24	0.22	1.21 (0.912; 1.61)	0.1845	CD37	intron
rs4149338	T/C	0.30	0.33	1.15 (0.88; 1.51)	0.3178	ABCA1	3′UTR
rs832573	T/C	0.34	0.29	1.13 (0.87; 1.45)	0.3583	MAP3K1	Intron
rs866223	A/G	0.43	0.38	1.09 (0.85; 1.40)	0.4870	MAP3K1	Intron
rs10195871	T/C	0.33	0.33	0.96 (0.74; 1.24)	0.7350	BCL11A	intron

Abbreviations: RAF risk allele frequency; OR, odds ratio; CI, confidence interval; 3′UTR, 3′ untranslated region. Note: A Bonferroni-adjusted P < 0.008 was considered significant to account for the six loci tested.

^*Adjusted for cardiopulmonary bypass, diagnosis, and population admixture.