Table 2.
Adherence and primary outcomes by treatment condition
| Placebo/ no CM1 |
Disulfiram / no CM |
Placebo/ CM | Disulfiram/ CM |
TOTAL | Disulfiram | CM | Disulfiram by CM |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | n=26 | n=28 | n=22 | n=23 | n=99 | |||||||||||
| mean | sd | mean | sd | mean | sd |
mea
n |
sd |
mea
n |
sd | F | p | F | p | F | p | |
|
Treatment adherence
indicators |
||||||||||||||||
| Days retained in treatment protocol2 |
24.9 | 31.0 | 43.1 | 37.5 | 36.7 | 33.4 | 43.2 | 35.7 | 36.9 | 34.9 | 3.13 | .08 | 0.73 | .40 | 0.70 | .40 |
| Mean percent days compliant with study medication |
90.4 | 12.5 | 87.3 | 15.8 | 89.2 | 18.6 | 88.4 | 11.8 | 88.7 | 14.7 | 0.33 | .57 | 0.00 | .98 | 0.11 | .74 |
| Percent treatment days of abstinence from alcohol, self-report |
91.6 | 16.7 | 88.1 | 23.0 | 93.4 | 21.5 | 90.0 | 23.1 | 90.6 | 20.9 | 0.58 | .45 | 0.16 | .69 | 0.00 | .99 |
| Primary outcome | ||||||||||||||||
| Percent treatment days abstinence from cocaine-self report |
72.2 | 27.3 | 79.2 | 18.1 | 91.1 | 13.6 | 69.6 | 31.7 | 77.8 | 24.4 | 2.02 | .16 | 0.85 | .36 | 7.84 | .01 |
| Secondary outcomes | ||||||||||||||||
| Percent cocaine-negative urines submitted3 |
28.7 | 36.8 | 39.5 | 40.8 | 60.5 | 35.3 | 41.2 | 40.3 | 43.1 | 39.3 | 0.08 | .79 | 4.74 | .03 | 2.19 | .14 |
| Percent of participants abstinent three or more continuous weeks (number, %) |
2 | 8.7% | 7 | 25% | 9 | 40.9% | 6 | 26.1% | 24 | 24.2 % |
1.10 | .30 | 0.01 | .93 | 3.7 | .05 |