Table 3.
Family history of breast cancer and cancer at six other sites in relation to risk of breast cancer.
| First degree family history of | Controls | Cases | ORa | (95% CI) |
|---|---|---|---|---|
| No cancer | 9,735 | 2,374 | 1.00 | Reference |
| One cancer site | ||||
| Breast cancer | 914 | 393 | 1.58 | (1.38–1.82) |
| Lung cancer | 869 | 250 | 1.19 | (1.01–1.39) |
| Prostate cancer | 863 | 244 | 1.16 | (0.99–1.36) |
| Colorectal cancer | 624 | 171 | 1.17 | (0.97–1.41) |
| Ovarian cancer | 323 | 61 | 0.90 | (0.68–1.21) |
| Lymphoma or leukemia | 137 | 52 | 1.25 | (0.88–1.78) |
| Cervical cancer | 52 | 34 | 1.53 | (0.94–2.47) |
| Two cancer sites | ||||
| Breast/Prostate | 105 | 76 | 3.02 | (2.19–4.16) |
| Breast/Lung | 126 | 52 | 1.60 | (1.13–2.27) |
| Breast/Colorectal | 83 | 32 | 1.40 | (0.89–2.22) |
| Breast/Ovarian | 51 | 11 | 1.21 | (0.62–2.37) |
| Breast/Lymphoma or leukemia | 16 | 10 | 1.42 | (0.60–3.33) |
| Breast/Cervical | 5 | 7 | 3.56 | (0.99–12.85) |
| Prostate/Colorectal | 119 | 37 | 1.52 | (1.03–2.24) |
| Prostate/Lung | 73 | 25 | 1.54 | (0.95–2.50) |
| Prostate/Ovarian | 28 | 12 | 1.95 | (0.94–4.02) |
| Prostate/Lymphoma or leukemia | 17 | 9 | 2.39 | (1.02–5.60) |
| Lung/Colorectal | 91 | 17 | 0.91 | (0.53–1.55) |
| Colorectal/Ovarian | 27 | 10 | 1.73 | (0.81–3.70) |
| 2 sites other than breast | 88 | 24 | 0.94 | (0.58–1.54) |
| Three or more cancer sites | ||||
| Breast/Prostate/Lung | 17 | 11 | 3.05 | (1.35–6.89) |
| Breast/Lung/Colorectal | 17 | 9 | 2.60 | (1.12–6.03) |
| Breast and 2 other sitesb | 74 | 38 | 2.39 | (1.57–3.64) |
| ≥3 sites other than breast | 47 | 15 | 1.37 | (0.74–2.54) |
a
Multivariable model adjusts for age, study, geographic region, questionnaire time period, and recency of mammogram
b
Other than the listed combinations of cancer sites