Table 4.
Family history of breast cancer and six other sites in relation to risk of breast cancer subtypes.
| ER+ | ER− | Triple negative | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||
| First degree family history of | Controls N | Cases N | ORa | (95% CI) | Cases N | ORa | (95% CI) | Cases N | ORa | (95% CI) |
| No cancer | 9,735 | 1,579 | 1.00 | Reference | 795 | 1.00 | Reference | 393 | 1.00 | Reference |
| One cancer site | ||||||||||
| Breast cancer | 914 | 270 | 1.62 | (1.39–1.89) | 123 | 1.50 | (1.21–1.86) | 65 | 1.55 | (1.17–2.06) |
| Lung cancer | 869 | 173 | 1.20 | (1.00–1.44) | 77 | 1.14 | (0.89–1.48) | 40 | 1.20 | (0.85–1.69) |
| Prostate cancer | 863 | 179 | 1.24 | (1.04–1.48) | 65 | 0.98 | (0.75–1.28) | 30 | 0.92 | (0.62–1.35) |
| Colorectal cancer | 624 | 119 | 1.19 | (0.96–1.47) | 52 | 1.12 | (0.83–1.52) | 21 | 0.92 | (0.58–1.46) |
| Ovarian cancer | 323 | 37 | 0.79 | (0.56–1.13) | 24 | 1.15 | (0.74–1.78) | 15 | 1.53 | (0.89–2.65) |
| Lymphoma or leukemia | 137 | 34 | 1.23 | (0.83–1.84) | 18 | 1.29 | (0.77–2.19) | 10 | 1.37 | (0.70–2.70) |
| Cervical cancer | 52 | 13 | 0.95 | (0.50–1.80) | 21 | 2.56 | (1.44–4.53) | 14 | 3.04 | (1.57–5.87) |
| Two cancer sites | ||||||||||
| Breast/Prostate | 105 | 60 | 3.40 | (2.42–4.79) | 16 | 2.09 | (1.21–3.63) | 6 | 1.60 | (0.69–3.74) |
| Breast/Lung | 126 | 31 | 1.37 | (0.91–2.08) | 21 | 2.11 | (1.29–3.46) | 16 | 3.32 | (1.89–5.84) |
| Breast/Colorectal | 83 | 26 | 1.67 | (1.03–2.71) | 6 | 0.80 | (0.33–1.92) | 3 | 0.74 | (0.22–2.45) |
| Breast/Ovarian | 51 | 9 | 1.43 | (0.69–2.96) | 2 | 0.70 | (0.17–2.93) | 1 | 0.79 | (0.11–5.82) |
| Prostate/Colorectal | 119 | 29 | 1.64 | (1.07–2.51) | 8 | 1.19 | (0.57–2.46) | 5 | 1.70 | (0.68–4.26) |
| Prostate/Lung | 73 | 19 | 1.61 | (0.95–2.74) | 6 | 1.34 | (0.57–3.15) | 4 | 1.89 | (0.67–5.30) |
| Lung/Colorectal | 91 | 11 | 0.80 | (0.42–1.52) | 6 | 1.20 | (0.52–2.80) | 2 | 0.85 | (0.21–3.53) |
| 2 other sitesb | 181 | 47 | 1.41 | (1.00–1.98) | 25 | 1.55 | (0.99–2.43) | 10 | 1.19 | (0.61–2.33) |
| Three or more cancer sites | ||||||||||
| Breast/≥2 sites other than breast | 108 | 40 | 2.42 | (1.65–3.56) | 18 | 2.78 | (1.65–4.68) | 8 | 2.65 | (1.26–5.60) |
| ≥3 sites other than breast | 47 | 8 | 1.04 | (0.48–2.26) | 7 | 2.23 | (0.97–5.12) | 2 | 1.39 | (0.33–5.92) |
a
Multivariable models adjust for age, study, geographic region, questionnaire time period, and recency of mammogram
b
Other than the listed combinations of cancer sites